PracticeUpdate: Diabetes

CONTENTS 5

RESEARCH Editor’s picks 6 30-Year Cost-Effectiveness Associated With Excellent Glycemic Control in Type 1 Diabetes Comment by Pooyan Kazemian PhD 7 Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function

COVER 6 30-Year Cost-Effectiveness Associated With Excellent Glycemic Control in Type 1 Diabetes Comment by Pooyan Kazemian PhD

CONFERENCE 18

17 Hypertension and Lipids in Diabetic Patients With CVD Interview with Benjamin Morgan Scirica MD Glycemic Variability Throughout the Night By the PracticeUpdate Editorial Team 23 Youth With Type 1 Diabetes Can Have Insulin Resistance By the PracticeUpdate Editorial Team 24 Testing for Gestational Diabetes Mellitus Early in Pregnancy Is Necessary By the PracticeUpdate Editorial Team 24 Enteroendocrine Function of the Intestine By Jason Sloane MD 25 Intensive Glycemic Control During Pregnancy By Jason Sloane MD 26 Inpatient Diabetes Management Guidelines – Use of the Insulin Pump and CGM By Jason Sloane MD 26 Long-Term Implantable Continuous Glucose Monitoring System Safe and Accurate in Teens With Type 1 Diabetes By the PracticeUpdate Editorial Team 22 American Diabetes Association 78th Scientific Sessions 22 Use of Insulin Analogs Provides Less

American Association of Clinical Endocrinologists Annual Meeting By the PracticeUpdate Editorial Team

8 Add-On Antihypertensive Medications to Angiotensin–Aldosterone System Blockers in Diabetes Comment by Jan N. Basile MD 9 Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary CTA 10 PD-1 Inhibitor-Induced Type 1 Diabetes Comment by Jason Sloane MD 11 Cognitive Function Deficits Associated With Long-Duration Type 1 Diabetes and Vascular Complications Comment by Naomi Sage Chaytor PhD, ABPP 12 Decreasing Rates of Major Lower-Extremity Amputation in People With Diabetes By Michael T. Watkins MD, FACS, FAHA 13 Diabetes in Individuals With Cystic Fibrosis: A Review Comment by Melissa S. Putman MD, MSc

EXPERT OPINION 16 Sequencing Injectable Therapies in Type 2 Diabetes Interview with John (Jack) L. Leahy MD by Jason Sloane MD 18 Type 2 Diabetes Patients Respond to Hydroxychloroquine 19 High Incidence of Ipilimumab-Induced Hypophysitis Documented in Large Cohort Study of Patients With Metastatic Melanoma 20 Thyroid Nodule Location a Predictive Risk Factor for Malignancy 20 Nodule Size Not Linked to Risk of Thyroid Cancer 21 Patients With Low PTH and Calcium Levels After Total Thyroidectomy at Higher Risk for Developing Hypocalcemia and Permanent Hypoparathyroidism

14 Reduced Risk of Heart Failure With

Intensified Multifactorial Intervention in Individuals With T2D and Microalbuminuria

15 Canagliflozin and Renal Outcomes in Type 2 Diabetes 15 Hypoglycemia Associated With Risk of

Cardiac Arrhythmia in Patients With Diabetes Mellitus

VOL. 2 • NO. 3 • 2018