PracticeUpdate Oncology Best of 2018

CONTENTS 3

EDITOR’S PICKS 10 Pertuzumab and Trastuzumab With or Without Metronomic Chemotherapy for Older Patients With HER2-Positive Metastatic Breast Cancer Comments by Reshma L. Mahtani DO and Lillie D. Shockney RN, BS, MAS 11 Pathological Response and Survival in TNBC After Neoadjuvant Carboplatin + Docetaxel Comment by Lee S. Schwartzberg MD, FACP 21-Gene Expression Assay in Breast Cancer Comment by Lee S. Schwartzberg MD, FACP 13 Enzalutamide Decreases Risk of Metastasis and Death in Men With Nonmetastatic CRPC Comment by Emmanuel Antonarakis MD 14 Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer Comment by Annette Hasenburg Prof. Dr. med 15 Hyperprogressive Disease in Advanced NSCLC Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy Comment by Axel Grothey MD 16 Pembrolizumab vs Paclitaxel for Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer Comment by Axel Grothey MD 19 Edoxaban for the Treatment of Cancer- Associated Venous Thromboembolism Comment by Rakhi Naik MD, MHS 12 Adjuvant Chemotherapy Guided by a

CONFERENCE 24 American Society of Clinical Oncology Annual Meeting 24 Lung Cancer Studies at ASCO 2018 By Annette Hasenburg Prof. Dr. med. 26 10 Practice Changes That I Will Make After Attending ASCO 2018 By Jeffrey J. Kirshner MD, FACP 28 23rd Congress of The European Hematology Association By the PracticeUpdate Editorial Team 28 Consider Obinutuzumab Plus Chlorambucil for First-Line Treatment for CLL 29 Rituximab Yields Durable Response in Adults With Persistent or Chronic Immune Thrombocytopenia 30 Response Rates Improve Significantly With Three-Drug Combination for DLBCL 31 European Society For Medical Oncology 2018 Congress 31 Pembrolizumab for Recurrent HNSCC Interview with Barbara Ann Burtness MD by Tyeese L. Gaines DO 32 T-VEC in Early Metastatic Melanoma Interview with Alexander van Akkooi MD, PhD by Tyeese L. Gaines DO 32 Overall Survival With Palbociclib Plus Fulvestrant Interview with Timothy J. Pluard MD by Bradley McGregor MD 33 American Society for Radiation Oncology 2018 Annual Meeting By the PracticeUpdate Editorial Team 33 In Patients With DCIS, Radiotherapy Cuts Low Recurrence Risk by Half 34 High-Dose Radiotherapy Improves Survival Substantially in Patients With Oligometastatic Cancer 35 Radiation + Cisplatin Established as Standard of Care for HPV-Related Head and Neck Cancer Interview with Wilfried Eberhardt MD by Farzanna S. Haffizulla MD, FACP, FAMWA 25 Best in Ovarian Cancer

TOP STORIES 2018 6 Venetoclax for Multiple Myeloma By Rafael D. Fonseca MD

EXPERT OPINION 20 Adjuvant Chemotherapy or Adjuvant Chemoradiotherapy for Gastric Cancer? – A West Cancer Center Perspective Interview with Bradley G. Somer MD by Erin Schenk MD, PhD 21 Dr. Sara Hurvitz on Management of HER2-Positive Breast Cancer With Brain Metastases Interview with Sara A. Hurvitz MD 6 Renal Cell Carcinoma: Ipilimumab + Nivolumab By Eric Jonasch MD 7 PD-1 Blockade With Cemiplimab for Advanced SCC of the Skin By Roxana S. Dronca MD 8 Hematologic Malignancies: Haploidentical Stem Cell Transplant By Isabel Cunningham MD 8 ER-Positive, Node-Negative Breast Cancer By Jeffrey J. Kirshner MD, FACP

22 Dr. Sara Hurvitz on

Management of HER2-Positive Metastatic Breast Cancer

Interview with Sara A. Hurvitz MD by Ana C. Sandoval Leon MD 22 An Overview of Chemotherapy- Induced Heart Failure Interview with Joerg Herrmann MD by Jennifer N. Caudle DO 23 Evidence-Based Chemotherapy for Oligometastatic Prostate Cancer Interview with Tanya B. Dorff MD by Farzanna S. Haffizulla MD, FACP, FAMWA

VOL. 2 • NO. 4 • 2018